PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction.

M yocardial infarction (MI) remains one of the most common health emergencies, and a sizable fraction of acute MI patients develop subsequent complications (1). Despite guideline-adherent therapy, post-MI heart failure occurs, motivating efforts to identify patients at risk and to develop novel therapeutic strategies. Increasingly, cardiologists are looking at the immune system’s role in the repair of the ischemic heart, and systemic inflammatory networks that could be targeted to oppose progression of ischemic heart disease. Two hurdles block our path to new therapeutics: the heterogeneity of the immune response in individual patients, and the detrimental as well as